Regulation of Actomyosin Ring Formation during Cytokinesis by Iqg1 and Phosphorylation
Department
Chemistry
Major
Chemistry
Research Advisor
Shannon, Katie
Advisor's Department
Biological Sciences
Abstract
Cytokinesis is the division of a cell into two daughter cells. Budding yeast is a useful model organism because, like higher eukaryotes, it requires an actomyosin ring. My research focuses on Iqg1, which is required for cytokinesis and is related to IQGAP proteins in human cells. Phosphorylation of Iqg1 has been shown to regulate the proper timing of assembly of the actomyosin ring. One aim of my project was to investigate the function of Iqg1 phosphorylation at specific amino acids in cytokinesis. The second goal was to determine the effect of phosphorylation on binding of Iqg1 to formin proteins, Bnr1 and Bni1. This research is important for the understanding the regulation of cytokinesis and how this process can be perturbed in cancer cells.
Biography
Madeline, Maddie, Hines is a graduating senior from the chemistry department. She has an emphasis in Biochemistry. She choose to work in Dr. Shannon’s research lab to gain biology lab skills which she hopes to use in the future for cancer research.
Research Category
Sciences
Presentation Type
Poster Presentation
Document Type
Poster
Award
Sciences poster session, First place
Location
Upper Atrium
Presentation Date
17 Apr 2018, 9:00 am - 12:00 pm
Regulation of Actomyosin Ring Formation during Cytokinesis by Iqg1 and Phosphorylation
Upper Atrium
Cytokinesis is the division of a cell into two daughter cells. Budding yeast is a useful model organism because, like higher eukaryotes, it requires an actomyosin ring. My research focuses on Iqg1, which is required for cytokinesis and is related to IQGAP proteins in human cells. Phosphorylation of Iqg1 has been shown to regulate the proper timing of assembly of the actomyosin ring. One aim of my project was to investigate the function of Iqg1 phosphorylation at specific amino acids in cytokinesis. The second goal was to determine the effect of phosphorylation on binding of Iqg1 to formin proteins, Bnr1 and Bni1. This research is important for the understanding the regulation of cytokinesis and how this process can be perturbed in cancer cells.
