Abstract
Avoparcin is a macrocyclic glycopeptide antibiotic structurally related to vancomycin, teicoplanin, and ristocetin A. When attached to 5-μm spherical silica gel, the avoparcin proved to be an effective chiral stationary phase (CSP) that could be used in the reversed-phase, normal- phase, and polar-organic modes. The avoparcin CSP was complimentary to the other macrocyclic glycopeptide CSPs in that it could resolve some racemates that the others could not, and vice versa. Some important compounds resolved on the avoparcin CSP include verapamil, thyroxine, mephenytoin, and 2- imidazolidone-4-carboxylic acid. The use of this CSP and the optimization of separations on it are discussed. Avoparcin appears to be a useful addition to this family of CSPs.
Recommended Citation
K. H. Ekborg-Ott et al., "Evaluation of the Macrocyclic Antibiotic Avoparcin as a New Chiral Selector for HPLC," Chirality, vol. 10, no. 7, pp. 627 - 660, Wiley, Oct 1998.
The definitive version is available at https://doi.org/10.1002/(SICI)1520-636X(1998)10:7<627::AID-CHIR10>3.0.CO;2-1
Department(s)
Chemistry
Publication Status
Full Access
Keywords and Phrases
Avoparcin; Chiral stationary phases; Enantiomeric separations; Macrocyclic antibiotics; Mephenytoin; Thyroxine; Verapamil
International Standard Serial Number (ISSN)
0899-0042
Document Type
Article - Conference proceedings
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Wiley, All rights reserved.
Publication Date
07 Oct 1998
PubMed ID
9757575
Comments
National Institute of General Medical Sciences, Grant R01GM053825