Abstract
Rapid degradation of magnesium (Mg) alloys is the major drawback preventing these materials from being applicable as tissue engineering scaffolds. In order to resolve this issue, in this paper, porous Mg scaffolds coated by polycaprolactone (PCL) were synthesized and their material properties and in vitro biodegradation were fully examined. The results indicated that PCL coating can significantly enhance the compressive strength and degradation resistance of Mg scaffolds. We showed that while the uncoated Mg scaffold degrades completely (100% weight loss) after 72 h, the degradation (weight loss) of the Mg scaffolds coated by 3% and 6% PCL is only 36% and 23%, respectively. Thus PCL-coated Mg scaffolds, as a biodegradable metal scaffold, can potentially have a promising application in bone tissue engineering.
Recommended Citation
M. Yazdimamaghani et al., "Development And Degradation Behavior Of Magnesium Scaffolds Coated With Polycaprolactone For Bone Tissue Engineering," Materials Letters, vol. 132, pp. 106 - 110, Elsevier, Oct 2014.
The definitive version is available at https://doi.org/10.1016/j.matlet.2014.06.036
Department(s)
Chemical and Biochemical Engineering
Publication Status
Full Text Access
Keywords and Phrases
Biodegradation; Biomaterials; Bone tissue engineering; Magnesium; Scaffold
International Standard Serial Number (ISSN)
0167-577X
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
01 Oct 2014
Comments
National Science Foundation, Grant 0933763