Abstract
Electro spun fiber scaffolds crafted from polyesters are studied extensively for potential tissue engineering applications. For translation of electro spun fibers into the clinic, the FDA requires analysis and quantification of any organic solvent that may be retained in the fibers since many organic solvents can negatively affect cells and tissues. If a significant amount of solvent is retained, then developing procedures for efficient solvent removal may enhance the clinical potential of these materials. In this study we use fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and nuclear magnetic resonance spectroscopy (NMR) to analyze solvent retention. A correlative analysis shows that both FTIR and TGA accurately predicted retention of two different solvents (HFP and chloroform) in our electro spun PLLA scaffolds, thus validating these procedures. We also assess the efficacy of various fiber treatment methods to facilitate organic solvent removal and conclude that submersion in 70 % ethanol and heat treatment at 100 °C were the most efficient methods of removing solvent from electro spun PLLA fibers.
Recommended Citation
A. R. D'Amato et al., "Evaluation of Procedures to Quantify Solvent Retention in Electrospun Fibers and Facilitate Solvent Removal," Fibers and Polymers, vol. 18, no. 3, pp. 483 - 492, Springer, Mar 2017.
The definitive version is available at https://doi.org/10.1007/s12221-017-1061-5
Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
Electrospinning; FTIR; NMR; Solvent retention; TGA
International Standard Serial Number (ISSN)
1229-9197
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Springer, All rights reserved.
Publication Date
01 Mar 2017
Comments
National Science Foundation, Grant 1150125