Abstract
A major challenge in developing drug-releasing electro spun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small molecule drugs from electro spun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small molecule drug, 6-aminonicotinamide (6AN), from PLLA fibers. Specifically, untreated fibers released 6AN over 9 days, and fibers that underwent a combined treatment of maintenance in a laboratory setting and heating released 6AN over 44 days. The unique and simple method presented here prolongs diffusive release of a small molecule drug from electro spun fibers and has potential to assist in lengthening small molecule drug release from a variety of polymeric nanomaterials.
Recommended Citation
A. R. D'Amato et al., "Removal of Retained Electrospinning Solvent Prolongs Drug Release from Electrospun PLLA Fibers," Polymer, vol. 123, pp. 121 - 127, Elsevier, Aug 2017.
The definitive version is available at https://doi.org/10.1016/j.polymer.2017.07.008
Department(s)
Chemical and Biochemical Engineering
Publication Status
Full Text Access
Keywords and Phrases
Biomaterials; Drug delivery; Electrospun fibers
International Standard Serial Number (ISSN)
0032-3861
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
11 Aug 2017
