Investigation of Cytotoxicity of Nanodiamonds by using Human Lung Cancer Cells and Advanced Analytical Techniques
Department
Chemistry
Major
Chemistry and Biology
Research Advisor
Ma, Yinfa
Advisor's Department
Chemistry
Funding Source
Missouri S&T OURE program, the Center for Single Cell, Single Particle, and Single Molecule Monitoring, and the Center for Biomedical Research
Abstract
In recent years, nanodiamonds have been studied for their applications in biology and medicine due to their unique electronic, mechanical, and surface chemistry properties. Their uses have been explored in many different areas, such as bone tissue engineering and drug delivery, electronics, sensors, solar cells, and many others, and their applications appear promising. However, a full and complete understanding of their toxicity to human and ecological system is required before their applications become practical. In this project, we have investigated the cytotoxic effect of different types of nanodiamonds at different doses, and different exposure times by using adenocarcinomic human alveolar basal epithelial cells (A549 Cells). In our experiments, four differently functionalized nanodiamonds at 50 to 250 μg/mLhave been dosed to A549 human lung cancer cells with exposure times ranging from 6 to 72 hours. The study results will be very helpful to the researchers who use nanodiamonds for biomedical applications.
Biography
Zachary Foulks is a sophomore undergraduate at Missouri S&T double majoring in both chemistry and biology. He has been involved in research with Dr. Ma’s group for over a year, and he has also been involved in the Schrenk Society for several months. He plans to pursue an MD/PhD degree once he graduates.
Research Category
Sciences
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium
Presentation Date
17 Apr 2018, 9:00 am - 12:00 pm
Investigation of Cytotoxicity of Nanodiamonds by using Human Lung Cancer Cells and Advanced Analytical Techniques
Upper Atrium
In recent years, nanodiamonds have been studied for their applications in biology and medicine due to their unique electronic, mechanical, and surface chemistry properties. Their uses have been explored in many different areas, such as bone tissue engineering and drug delivery, electronics, sensors, solar cells, and many others, and their applications appear promising. However, a full and complete understanding of their toxicity to human and ecological system is required before their applications become practical. In this project, we have investigated the cytotoxic effect of different types of nanodiamonds at different doses, and different exposure times by using adenocarcinomic human alveolar basal epithelial cells (A549 Cells). In our experiments, four differently functionalized nanodiamonds at 50 to 250 μg/mLhave been dosed to A549 human lung cancer cells with exposure times ranging from 6 to 72 hours. The study results will be very helpful to the researchers who use nanodiamonds for biomedical applications.
