Conversion of Bioactive Borosilicate Glass to Multilayered Hydroxyapatite in Dilute Phosphate Solution

Abstract

The conversion of a bioactive borosilicate glass in aqueous phosphate solution was observed to produce vastly different reaction kinetics and hydroxyapatite (HA) microstructures, depending on whether the glass was reacted continuously or intermittently in the solution. Particles (150-300 μm) of a borosilicate glass (designated H12) were reacted continuously or intermittently in 0.25M K2HPO4 solution with a starting pH value of 7.0 at 37°C. The conversion kinetics of the glass particles to HA were determined from weight loss measurements. Structural and compositional changes resulting from the conversion reaction were characterized using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray analysis, and Fourier transform infrared spectroscopy. For conversion experiments carried out intermittently (12-24 h intervals, followed by drying), faster reaction kinetics and a unique multilayered microstructure, consisting of alternating layers of HA and an amorphous SiO2-rich material with nearly uniform thickness (2-3 μm), were observed. On the other hand, particles reacted continuously in the phosphate solution for the same total time converted more slowly and produced a single HA layer. The kinetics and mechanism of forming HA under the intermittent and continuous reaction conditions are described and compared with those for bioactive silicate and borate glasses studied in previous work.

Department(s)

Materials Science and Engineering

Keywords and Phrases

Aqueous Phosphate Solution; Borosilicate Glass

International Standard Serial Number (ISSN)

0002-7820; 1551-2916

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2007 American Ceramic Society, All rights reserved.

Publication Date

01 Jan 2007

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