Modelling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials : Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies

Author

Patrick P. Sheehan

Keywords and Phrases

Freeze drying in vials; Lyophilization in vials; Surface geometry of moving interface; Velocity of moving interface; Distribution of bound water

Abstract

"A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. The results in this work strongly motivate the aggressive control of freeze drying, and it is found that heat input control that runs the process close to the melting and scorch temperature constraints yields (i) faster drying times, and (ii) more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage"--Abstract, page iv.

Advisor(s)

Liapis, Athanasios I.

Committee Member(s)

Reed, X. B., Jr.
Avula, Xavier J. R.

Department(s)

Chemical and Biochemical Engineering

Degree Name

M.S. in Chemical Engineering

Publisher

University of Missouri--Rolla

Publication Date

Spring 1998

Pagination

xii, 239 pages

Note about bibliography

Includes bibliographical references.

Rights

© 1998 Patrick Paul Sheehan, All rights reserved.

Document Type

Thesis - Restricted Access

File Type

text

Language

English

Subject Headings

Freeze-drying -- ResearchFreeze-drying -- Mathematical modelsDrying -- Mathematical modelsInterfaces (Physical sciences) -- Mathematical models

Thesis Number

T 7485

Print OCLC #

39631808

Electronic OCLC #

932257707

Recommended Citation

Sheehan, Patrick P., "Modelling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials : Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies" (1998). Masters Theses. 1727.
https://scholarsmine.mst.edu/masters_theses/1727