Abstract
“Mild Traumatic Brain Injury (mTBI) accounts for 70-90% of TBIs recorded in the last two decades. Subjection to continued mTBIs could result in severe comorbidities appearing years later. Current research on mTBI shows significant male sex and single age skew in murine animal models. Using the Missouri Blast Model, mice were inflicted with mTBI and evaluated using standard behavior tests and a novel method not previously used for mTBI with an open blast model. With both methods, a larger clinical difference was found between age groups than sex. We were also able to show that the novel tracking method was able to identify clinical symptoms in mice consistently while traditional methods were not. These results support a need for diversification of age ranges of future murine models for mTBI studies”--Abstract, page 2.
Advisor(s)
Semon, Julie A.
Committee Member(s)
Bode, Phillip
Westenberg, David J.
Stone, Nancy J.
Gragg, Larry Dale, 1950-
Department(s)
Biological Sciences
Publisher
Missouri University of Science and Technology
Pagination
18 pages
Note about bibliography
Includes bibliographical references (pages 17-18).
Document Version
Final Version
Rights
© 2022 Jennifer Harrell, All rights reserved.
Document Type
Honors Thesis
File Type
text
Language(s)
English
Institutions Name at Time of Publication
Missouri University of Science and Technology
Recommended Citation
Harrell, Jennifer, "Assessing the effects of age and sex on mTBI severity" (2022). Honors Academy. 2.
https://scholarsmine.mst.edu/honors_academy/2
