Doctoral Dissertations


Erik M. Erbe


"This dissertation is the culmination of the investigation of several aspects of the Y2O3-Al2O3-SiO2 (YAS) glass forming system. This glass system is of particular interest for use as a neutron-activatable glass capable of being used as a radiopharmaceutical. There has been some promising research using YAS glass microspheres for the localized treatment of liver cancer. The objective of this research is to further define and characterize the relevant glass properties in this system for use in the treatment of liver cancer and other radiation therapies.

The Y2O3-Al2O3-SiO2 system has been characterized previously by basic glass property evaluation. This dissertation investigates some of the specific properties related to the application and others of purely scientific interest more completely and in depth. The main body of this work will be presented in five papers that will be submitted for publication; the first on conventionally melted and sol-gel derived Y2O3-Al2O3-SiO2 glasses, the second on the formation of Y2O3-Al2O3-SiO2 glass microspheres by sol-gel, the third on the chemical durability of the Y2O3-Al2O3-SiO2 glasses for use in-vivo, and the fourth and fifth, a structural study of Y2O3-Al2O3-SiO2glasses made by conventional melting and sol-gel methods.

The first three papers cover the aspects of the Y2O3-Al2O3-SiO2 glass formation and characterization for use in radiopharmaceutical applications. The latter papers examine the structure of the Y2O3-Al2O3-SiO2 glasses and is of purely scientific interest"--Abstract, page iii.


Day, D. E.

Committee Member(s)

Moore, Robert E., 1930-2003
Rahaman, M. N., 1950-
Blum, Frank D.
Podzimek, Josef, 1923-2007
Ehrhardt, Gary


Materials Science and Engineering

Degree Name

Ph. D. in Ceramic Engineering


University of Missouri--Rolla

Publication Date

Spring 1991

Journal article titles appearing in thesis/dissertation

  • Conventionally Melted and Sol-Gel Derived Y2O3-Al2O3-SiO2 Glasses
  • Formation of Sol-Gel Derived Y2O3-Al2O3-SiO2 Glass Microspheres
  • Chemical Durability of Y2O3-Al2O3-SiO2 Glasses for the in-vivo Delivery of β Radiation
  • Structural Study of Conventionally Melted and Sol-Gel Derived Y2O3-Al2O3-SiO2 Glasses: I, 27Al & 29Si MAS NMR Spectra
  • Structural Study of Conventionally Melted and Sol-Gel Derived Y2O3-Al2O3-SiO2 Glasses: II, Raman and Infrared Spectra


xx, 195 pages

Note about bibliography

Includes bibliographical references.


© 1991 Erik Michael Erbe, All rights reserved.

Document Type

Dissertation - Restricted Access

File Type




Thesis Number

T 6399

Print OCLC #


Link to Catalog Record

Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.

Share My Dissertation If you are the author of this work and would like to grant permission to make it openly accessible to all, please click the button above.