Identifying Antigens and Antibodies in Serology

Author

George Markowsky, Missouri University of Science and TechnologyFollow
Andrew Wohlgemuth

Abstract

The problem of whether it is theoretically possible to determine antigens and antibodies in a cross-reacting serological system is analyzed. Conditions are listed which will insure that the serological operations of absorption, elution, blocking, and counterblocking uniquely determine antigens and antibodies. There is no restriction on cross-reactivity. The protocol for counterblocking was given by Denniston and has not been developed by serologists. Denniston has shown that counterblocking can be replaced by combinations ofthe other operations in a system where there can be no cross-reactivity. This paper indicates the potential usefulness of such a technique.

Recommended Citation

G. Markowsky and A. Wohlgemuth, "Identifying Antigens and Antibodies in Serology," Mathematical Biosciences, vol. 66, no. 2, pp. 273 - 282, Elsevier, Oct 1983.

The definitive version is available at https://doi.org/10.1016/0025-5564(83)90093-7

Department(s)

Computer Science

Keywords and Phrases

Immunology; Antibody; Antigen; Nonbiological Model; Nonhuman

International Standard Serial Number (ISSN)

0025-5564

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1983 Elsevier, All rights reserved.

Publication Date

01 Oct 1983