Targeting Triple Negative Breast Cancer Cells by N³-substituted 9, 10-Phenanthrenequinone Thiosemicarbazones and their Metal Complexes

Abstract

Novel N3-substituted 9, 10-Phenanthrenequinone thiosemicarbazones and their copper, nickel and palladium complexes are structurally characterized and reported along with the single crystal X-ray structures of three ligands and one nickel complex. All compounds were evaluated for their antiproliferative potential against Triple Negative Breast Cancer (TNBC) cells which have poor prognosis and no effective drugs to treat with. All compounds exhibited antiproliferative activity against these cells. Among the metal complexes evaluated, redox active copper complexes were found to be more potent. The possible mechanism for such enhanced activity can be attributed to the generation of oxidative stress, which was amenable for targeting through metal complexation.

Department(s)

Chemistry

Keywords and Phrases

9 ,10-Phenanthrenequinone; Anti-proliferative Activities; Copper Complexes; Thiosemicarbazones; Triple-negative Breast Cancers, Amines; Copper; Diseases; Metal Complexes; Nickel; Phenols; Redox Reactions, Palladium Compounds; 9,10-Phenanthrenequinone; Antiproliferative Activity; Copper Complex; N3-substituted Thiosemicarbazones; Triple Negative Breast Cancer

International Standard Serial Number (ISSN)

1386-1425

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2013 Elsevier, All rights reserved.

Publication Date

01 Oct 2013

Link to Full Text

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