Metal-based Anticancer Agents: Targeting Androgen-dependent and Androgen-independent Prostate and COX-positive Pancreatic Cancer Cells by Phenanthrenequinone Semicarbazone and its Metal Complexes

Abstract

A planar, polycyclic and aromatic hydrocarbon ligand, namely 9,10-phenanthrenequinone semicarbazone, and its transition metal complexes have been synthesized and structurally characterized. The in vitro antiproliferative activity of these compounds against five human cancer cell lines revealed that they were effective against androgen receptor-positive/negative prostate cancer cells as well as COX-positive pancreatic BxPC-3 cancer cell line. The driving force behind such antiproliferative activity seems to be the up-regulated COX expression in these cells, which was amenable for targeting through metal complexation. These structural motifs can, therefore, serve as a starting point for developing novel cytotoxic agents against the growing number of prostate and pancreatic cancers.

Department(s)

Chemistry

Keywords and Phrases

9 ,10-Phenanthrenequinone; Androgen-dependent; Anti-cancer agents; Anti-proliferative activities; Human cancer cells; Pancreatic cancers; Phenanthrenequinone; Prostate cancer cells; Cell culture; Cytotoxicity; Diseases; Metal complexes; Transition metal compounds; Urology; Cells

International Standard Serial Number (ISSN)

0340-4285

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2013 Springer Verlag, All rights reserved.

Publication Date

01 Sep 2013

Link to Full Text

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