Gadolinium Triflate: An Efficient and Convenient Catalyst for Acetylation of Alcohols and Amines

Author

Ramesh Alleti
Meher Perambuduru
Sampak Smantha
Prakash Reddy, Missouri University of Science and TechnologyFollow

Abstract

Gadolinium triflate (Gd(OTf) ₃) was found to be a simple and efficient catalyst for the acetylation of alcohols and amines. Acetylation reactions using acetic anhydride as the reagent proceed in excellent yields, in the presence of catalytic amounts (0.01-0.1 mol%) of Gd(OTf) ₃, at ambient temperature. Aliphatic alcohols as well as phenols and amines undergo acetylations under mild conditions. The intermediate formation of the mixed anhydride, acetic trifluoromethanesulfonic anhydride was demonstrated by ¹³C NMR spectroscopy experiments.

Recommended Citation

R. Alleti et al., "Gadolinium Triflate: An Efficient and Convenient Catalyst for Acetylation of Alcohols and Amines," Journal of Molecular Catalysis A: Chemical, vol. 226, no. 1, pp. 57 - 59, Elsevier, Feb 2005.

The definitive version is available at https://doi.org/10.1016/j.molcata.2004.09.024

Department(s)

Chemistry

Sponsor(s)

Petroleum Research Fund

Keywords and Phrases

Acetic anhydride; Acetic trifluoromethanesulfonic anhydride; Acetylation; Gadolinium triflate; Lewis acid

International Standard Serial Number (ISSN)

1381-1169

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2005 Elsevier, All rights reserved.

Publication Date

01 Feb 2005