Nickel (II) Complexes of Naphthaquinone Thiosemicarbazone and Semicarbazone: Synthesis, Structure, Spectroscopy, and Biological Activity

Abstract

Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. the X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. in vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.

Department(s)

Chemistry

Keywords and Phrases

antineoplastic agent; naphthaquinone thiosemicarbazone; nickel complex; nickel(naphthaquinone semicarbazone); nickel(naphthaquinone thiosemicarbazone); semicarbazone; semicarbazone derivative; unclassified drug; antineoplastic activity; biological activity; cancer inhibition; cell proliferation; cell strain MCF 7; crystal structure; drug structure; drug synthesis; human; human cell; spectroscopy; X ray analysis; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Naphthoquinones; Nickel; Organometallic Compounds; Semicarbazones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiosemicarbazones, Mink cell focus-forming virus

International Standard Serial Number (ISSN)

0162-0134

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2005 Elsevier, All rights reserved.

Publication Date

01 Jul 2005

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