Abstract
This Communication describes the Pd-catalyzed C(sp3)-H functionalization of a tropane derivative to generate products with functionalization at two (β/γ) or three (β/γ/β) different sites on the alicyclic amine core. These reactions proceed via an initial dehydrogenation to generate an alkene product that can react further to form a Pd(I) alkene-bridged dimer. Functionalization of this dimer affords β/γ/β-functionalized allylic arylation and allylic acetoxylation products.
Recommended Citation
E. Y. Aguilera et al., "Transannular Functionalization Of Multiple C(sp3)-H Bonds Of Tropane Via An Alkene-Bridged Palladium(I) Dimer," Organometallics, vol. 42, no. 8, pp. 627 - 631, American Chemical Society, Apr 2023.
The definitive version is available at https://doi.org/10.1021/acs.organomet.3c00086
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1520-6041; 0276-7333
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 American Chemical Society, All rights reserved.
Publication Date
24 Apr 2023
Comments
National Science Foundation, Grant R35GM1361332