Use of a Macrocyclic Antibiotic as the Chiral Selector for Enantiomeric Separations by TLC
Abstract
The macrocyclic antibiotic, vancomycin, was used as a chiral mobile phase additive for the thin layer chromatographic (TLC) resolution of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatized amino acids, racemic drugs and dansyl-amino acids. Excellent separations were achieved for most of these compounds in the reversed phase mode. Both the nature of the stationary phase and the composition of the mobile phase strongly influenced enantiomeric resolution. The best results were obtained using diphenyl stationary phases. Acetonitrile was the organic modifier that produced the most effective separations with the shortest development times. It is highly likely that macrocyclic antibiotics will play a major role in future enantiomeric separations. © 1994, Taylor & Francis Group, LLC. All rights reserved.
Recommended Citation
D. W. Armstrong and Y. Zhou, "Use of a Macrocyclic Antibiotic as the Chiral Selector for Enantiomeric Separations by TLC," Journal of Liquid Chromatography, vol. 17, no. 8, pp. 1695 - 1707, Taylor and Francis Group; Taylor and Francis, Apr 1994.
The definitive version is available at https://doi.org/10.1080/10826079408013451
Department(s)
Chemistry
International Standard Serial Number (ISSN)
0148-3919
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Taylor and Francis Group; Taylor and Francis, All rights reserved.
Publication Date
01 Apr 1994
Comments
U.S. Department of Energy, Grant None