Abstract
Adsorptive bubble separation methods are known to be useful for processing large amounts of material at a relatively low cost These techniques have been used to enrich components from both heterogeneous and homogeneous solutions. There is a need for economical process-scale enantiomeric separations. Thus far there has been little evidence to support the feasibility of using an adsorptive bubble process to enrich enantiomers. We demonstrate that foam-forming chiral collectors can be used in conjunction with an inexpensive glass device to enantiomerically enrich some pharmaceutically important compounds as well as derivatized and underivatized amino acids. Factors that appeared to affect this water-based separation include the following: (a) column length, (b) column geometry and packing, (c) gas flow rate, (d) concentration of the collector and the racemate, (e) nature of the collector, (f) temperature, (g) pH, (h) reflux time, (i) foam dryness, and (j) the presence of other materials in the sample (e.g., miscible organic solvents, salts, etc.). The chiral collectors used in this study are known to be able to associate with analytes via ligand exchange interactions, hydrophobic inclusion complexation, and hydrogen-bonding interactions among others. © 1994, American Chemical Society. All rights reserved.
Recommended Citation
D. W. Armstrong et al., "Foam Flotation Enrichment of Enantiomers," Analytical Chemistry, vol. 66, no. 23, pp. 4278 - 4282, American Chemical Society, Dec 1994.
The definitive version is available at https://doi.org/10.1021/ac00095a025
Department(s)
Chemistry
International Standard Serial Number (ISSN)
1520-6882; 0003-2700
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 American Chemical Society, All rights reserved.
Publication Date
01 Dec 1994
