The Evolution of Chiral Stationary Phases for Liquid Chromatography

Abstract

The development of effective chiral stationary phases and separation strategies for liquid chromatography (LC) resolution of enantiomers has been beneficial to many scientific disciplines. During the past decade the number and type of chiral stationary phases have expanded tremendously. Not only have researchers introduced new classes of chiral selectors, but many of the first chiral stationary phases have also been changed and improved. The second or third generation of a chiral stationary phase is often different than the original. This evolution can be confusing and intimidating to someone new to LC enantiomeric separations. Fortunately, all chiral stationary phases can be categorized into a few classes. Generally, one or two columns can separate most samples in each class. In this article, the author looks at the different classes of chiral stationary phases and how they have expanded and changed during the last decade.

Department(s)

Chemistry

International Standard Serial Number (ISSN)

1471-6577

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 The Authors, All rights reserved.

Publication Date

01 Jan 1998

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