Abstract
The addition of an achiral crown ether (18-crown-6) to a cyclodextrin- based separation can significantly affect the capillary electrophoresis (CE) enantioresolution of organic racemates that contain a primary amine functional group. In most cases an enhancement of the enantioseparation was observed. However, there are also cases where the addition of 18-crown-6 was detrimental to a cyclodextrin-based CE enantioseparation. The effect of concentration of the two complexing additives as well as the effect of pH and added potassium ion were examined. A specific three-body complex involving simultaneous, dual inclusion complex formation can be used to explain both the enhanced and diminished enantioselectivities observed when 18-crown-6 is added to the run buffer.
Recommended Citation
D. W. Armstrong et al., "Mechanism of Capillary Electrophoresis Enantioseparations using a Combination of an Achiral Crown Ether Plus Cyclodextrins," Journal of Chromatography A, vol. 793, no. 1, pp. 115 - 134, Elsevier, Jan 1998.
The definitive version is available at https://doi.org/10.1016/S0021-9673(97)00826-1
Department(s)
Chemistry
Keywords and Phrases
Amines; Buffer composition; Chiral selectors; Crown ethers; Enantiomer separation
International Standard Serial Number (ISSN)
0021-9673
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2024 Elsevier, All rights reserved.
Publication Date
09 Jan 1998
PubMed ID
9468654
Comments
National Institutes of Health, Grant R01GM053825