Preliminary Pharmacology Of Ellagic Acid From Juglans Nigra (black Walnut)
Abstract
A crystalline compound was isolated from Juglans nigra which by comparison with the known compound was found to be ellagic acid. The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsive shock. Intravenous injection of ellagic acid caused a fall in blood pressure and an elevation of the T wave, whereas the heart and respiration rate initially increased followed by a decrease. The ellagic acid produced no significant effect on isolated duodenal and uterus segments of the rat. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company
Recommended Citation
U. C. Bhargava et al., "Preliminary Pharmacology Of Ellagic Acid From Juglans Nigra (black Walnut)," Journal of Pharmaceutical Sciences, vol. 57, no. 10, pp. 1728 - 1732, Elsevier, Jan 1968.
The definitive version is available at https://doi.org/10.1002/jps.2600571021
Department(s)
Chemistry
Keywords and Phrases
Ellagic acid—Juglans nigra; IR spectrophotometry—identity; Pharmacologic screening—ellagic acid; UV spectrophotometry—identity
International Standard Serial Number (ISSN)
1520-6017; 0022-3549
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2023 Elsevier, All rights reserved.
Publication Date
01 Jan 1968
PubMed ID
5693427
Comments
National Institutes of Health, Grant NY-4295