Enantiomeric Composition of Nicotine in Smokeless Tobacco, Medicinal Products, and Commercial Reagents
Abstract
The enantiomeric composition of nicotine in 18 smokeless tobaccos, 3 strains of tobacco leaf, 8 pharmaceutical products, and 4 commercial reagents was determined. The relative amount of the minor enantiomeric component, (R)-(+)-nicotine, ranged from 0.1% to 1.2% of the total nicotine in all samples. In some cases it appears that (R)-(+)-nicotine may be considered one of the five most common alkaloids in tobacco products. The highest level of (R)-(+)-nicotine was found in a commercial transdermal patch. The extraction and purification processes used in obtaining commercial (S)-(-)-nicotine supplies from tobacco do not appear to decrease the amount of (R)-(+)-nicotine present.
Recommended Citation
D. W. Armstrong et al., "Enantiomeric Composition of Nicotine in Smokeless Tobacco, Medicinal Products, and Commercial Reagents," Chirality, John Wiley & Sons, Jan 1998.
Department(s)
Chemistry
Sponsor(s)
Smokeless Tobacco Research Council Inc
International Standard Serial Number (ISSN)
0899-0042
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 1998 John Wiley & Sons, All rights reserved.
Publication Date
01 Jan 1998
