Effects of Some Sulfur-containing Antioxidants on Lead-exposed Lenses

Author

Rachel Neal
Katherine Cooper
Gary Kellogg
Nuran Ercal, Missouri University of Science and TechnologyFollow
Hande Gürer-Orhan

Abstract

Lead (Pb) is known to negatively affect glutathione (GSH) metabolism in the lens. The present study examined the effects of Captopril, Taurine, and α-Lipoic acid on the Pb-induced GSH depletion and lipid peroxide increase in the lenticular system. Captopril administration returned the GSH, cysteine (CYS), and malondialdehyde (MDA) levels to near normal. Following Taurine administration the GSH, CYS and MDA levels were intermediate between the control group and the Pb group levels. α-Lipoic acid administration, however, only increased the CYS levels. No significant changes in oxidized glutathione (GSSG) levels were observed in any treatment group.

Recommended Citation

R. Neal et al., "Effects of Some Sulfur-containing Antioxidants on Lead-exposed Lenses," Free Radical Biology and Medicine, Elsevier, Jan 1999.

The definitive version is available at https://doi.org/10.1016/S0891-5849(98)00214-7

Department(s)

Chemistry

International Standard Serial Number (ISSN)

0891-5849

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1999 Elsevier, All rights reserved.

Publication Date

01 Jan 1999