Prescribed Nanoparticle Cluster Architectures and Low-Dimensional Arrays Built using Octahedral DNA Origami Frames

Abstract

Three-dimensional mesoscale clusters that are formed from nanoparticles spatially arranged in pre-determined positions can be thought of as mesoscale analogues of molecules. These nanoparticle architectures could offer tailored properties due to collective effects, but developing a general platform for fabricating such clusters is a significant challenge. Here, we report a strategy for assembling three-dimensional nanoparticle clusters that uses a molecular frame designed with encoded vertices for particle placement. The frame is a DNA origami octahedron and can be used to fabricate clusters with various symmetries and particle compositions. Cryo-electron microscopy is used to uncover the structure of the DNA frame and to reveal that the nanoparticles are spatially coordinated in the prescribed manner. We show that the DNA frame and one set of nanoparticles can be used to create nanoclusters with different chiroptical activities. We also show that the octahedra can serve as programmable interparticle linkers, allowing one- and two-dimensional arrays to be assembled with designed particle arrangements.

Department(s)

Chemistry

Keywords and Phrases

DNA; Electron microscopes, Cryo-electron microscopy; Nanoparticle clusters; Particle arrangements; Particle composition; Particle placement; Tailored properties; Three-dimensional nanoparticles; Two-dimensional arrays, Nanoparticles, complementary DNA; DNA; gold nanoparticle; nanoparticle; octahedral DNA; unclassified drug; DNA; nanocomposite; DNA A; gold nanoparticle; single stranded DNA, Article; chirality; cryoelectron microscopy; density; DNA sequence; DNA structure; DNA template; electron microscopy; histogram; molecular recognition; particle size; priority journal; radiation scattering; surface property; transmission electron microscopy; X ray crystallography; chemistry; conformation; crystallization; materials testing; procedures; three dimensional printing; ultrastructure; cluster analysis; DNA origami octahedron; nanoarray, Crystallization; DNA; Materials Testing; Nanocomposites; Nucleic Acid Conformation; Particle Size; Printing, Three-Dimensional

International Standard Serial Number (ISSN)

1748-3387; 1748-3395

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2015 Macmillan Publishers Limited, All rights reserved.

Publication Date

01 Jul 2015

PubMed ID

26005999

Link to Full Text

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