Carnosine: A Versatile Antioxidant and Antiglycating Agent
Abstract
Carnosine ({beta}-alanyl-L-histidine) has recently attracted much attention as a naturally occurring antioxidant and transition-metal ion sequestering agent. It has also been shown to act as an anti-glycating agent, inhibiting the formation of advanced glycation end products (AGEs). Through its distinctive combination of antioxidant and antiglycating properties, carnosine is able to attenuate cellular oxidative stress and can inhibit the intracellular formation of reactive oxygen species and reactive nitrogen species. by controlling oxidative stress, suppressing glycation, and chelating metal ions, carnosine is able to reduce harmful sequelae such as DNA damage. AGEs are known contributors to the pathology of Alzheimer's disease, and carnosine therefore merits serious attention as a possible therapeutic agent.
Recommended Citation
P. Reddy et al., "Carnosine: A Versatile Antioxidant and Antiglycating Agent," Science of Aging Knowledge Environment, vol. 2005, no. 18, p. pe12, American Association for the Advancement of Science (AAAS), May 2005.
The definitive version is available at https://doi.org/10.1126/sageke.2005.18.pe12
Department(s)
Chemistry
Keywords and Phrases
advanced glycation end product; antioxidant; carnosine; metal; transition element; aging; Alzheimer disease; DNA damage; drug antagonism; human; lipid peroxidation; oxidative stress; pathophysiology; review; Metals; Alzheimer's disease
International Standard Serial Number (ISSN)
1539-6150
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2005 American Association for the Advancement of Science (AAAS), All rights reserved.
Publication Date
01 May 2005
