Gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor® and Pyridinium Polyhydrogen Fluoride
Abstract
2,2-Diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving SelectfluorH and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.
Recommended Citation
P. Reddy et al., "Gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor® and Pyridinium Polyhydrogen Fluoride," Chemical Communications, no. 5, pp. 654 - 656, Royal Society of Chemistry, Feb 2005.
The definitive version is available at https://doi.org/10.1039/b414254c
Department(s)
Chemistry
Sponsor(s)
Petroleum Research Fund
University of Southern California. Loker Hydrocarbon Research Institute
Keywords and Phrases
1,3 dithiolane derivative; ketone derivative; pyridinium derivative; pyridinium polyhydrogen fluoride; sulfuryl chloride; sulfuryl chloride fluoride; unclassified drug; arylation; chemical modification; chemical structure; combinatorial chemistry; difluorination; fluorination; hydrolysis; quantitative analysis; structure analysis; Diazonium Compounds; Fluorine; Heterocyclic Compounds; Molecular Structure; Pyridinium Compounds
International Standard Serial Number (ISSN)
1359-7345
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2005 Royal Society of Chemistry, All rights reserved.
Publication Date
01 Feb 2005
