Title

Gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor® and Pyridinium Polyhydrogen Fluoride

Abstract

2,2-Diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving SelectfluorH and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.

Department(s)

Chemistry

Sponsor(s)

Petroleum Research Fund
University of Southern California. Loker Hydrocarbon Research Institute

Keywords and Phrases

1,3 dithiolane derivative; ketone derivative; pyridinium derivative; pyridinium polyhydrogen fluoride; sulfuryl chloride; sulfuryl chloride fluoride; unclassified drug; arylation; chemical modification; chemical structure; combinatorial chemistry; difluorination; fluorination; hydrolysis; quantitative analysis; structure analysis; Diazonium Compounds; Fluorine; Heterocyclic Compounds; Molecular Structure; Pyridinium Compounds

International Standard Serial Number (ISSN)

13597345

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2005 Royal Society of Chemistry, All rights reserved.

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