Genotoxicity Of Amorphous Silica Nanoparticles: Status And Prospects

Abstract

Amorphous silica nanoparticles (SNPs) are widely used in biomedical applications and consumer products. Little is known, however, about their genotoxicity and potential to induce gene expression regulation. Despite recent efforts to study the underlying mechanisms of genotoxicity of SNPs, inconsistent results create a challenge. A variety of factors determine particle–cell interactions and underlying mechanisms. Further, high-throughput studies are required to carefully assess the impact of silica nanoparticle physicochemical properties on induction of genotoxic response in different cell lines and animal models. In this article, we review the strategies available for evaluation of genotoxicity of nanoparticles (NPs), survey current status of silica nanoparticle gene alteration and genotoxicity, discuss particle-mediated inflammation as a contributing factor to genotoxicity, identify existing gaps and suggest future directions for this research.

Department(s)

Chemical and Biochemical Engineering

Comments

National Institute of Environmental Health Sciences, Grant R01ES024681

Keywords and Phrases

Gene expression profile; Genotoxicity; Inflammation; Silica nanoparticles; Structure–activity relationship

International Standard Serial Number (ISSN)

1549-9642; 1549-9634

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Elsevier, All rights reserved.

Publication Date

01 Feb 2019

PubMed ID

30529789

Link to Full Text

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