Understanding Peptide Biology: The Discovery and Characterization of the Novel Hormone, Neuronostatin

Author

Gina L.C. Yosten, Missouri University of Science and TechnologyFollow
Mollisa M. Elrick
Alison Salvatori
Lauren M. Stein
Grant R. Kolar, Missouri University of Science and TechnologyFollow
Jun Ren
John A. Corbett
Willis K. Samson

Abstract

The Human Genome Project provided the opportunity to use bioinformatic approaches to discover novel, endogenous hormones. Using this approach we have identified two novel peptide hormones and review here our strategy for the identification and characterization of the hormone, neuronostatin. We describe in this mini-review our strategy for determining neuronostatin's actions in brain, heart and pancreas. More importantly, we detail our deductive reasoning strategy for the identification of a neuronostatin receptor and our progress in establishing the physiological relevance of the peptide.

Recommended Citation

G. L. Yosten et al., "Understanding Peptide Biology: The Discovery and Characterization of the Novel Hormone, Neuronostatin," Peptides, vol. 72, pp. 192 - 195, Elsevier, Oct 2015.

The definitive version is available at https://doi.org/10.1016/j.peptides.2015.05.011

Department(s)

Biological Sciences

Comments

National Institutes of Health, Grant DK052194

Keywords and Phrases

Hypothalamus; Neuropeptides; Pituitary; Receptors

International Standard Serial Number (ISSN)

1873-5169; 0196-9781

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 Elsevier, All rights reserved.

Publication Date

01 Oct 2015

PubMed ID

26051024