The Melanocortins, not Oxytocin, Mediate the Anorexigenic and Antidipsogenic Effects of Neuronostatin
Abstract
Neuronostatin, a recently discovered peptide derived from the somatostatin preprohormone, significantly inhibited both food and water intake when administered centrally in adult male rats. Because neuronostatin is highly produced in the hypothalamus, an area of the brain through which important feeding circuits, including the central melanocortin system, communicate, we sought to determine if the anorexigenic and antidipsogenic effects of neuronostatin would be reversed by pretreatment with the melanocortin 3/4 receptor antagonist, SHU9119. SHU9119 pretreatment reversed the effect of neuronostatin on both food and water intake. We have shown recently that the central oxytocin system is a potential downstream mediator of the anorexignic action of alpha-MSH. We therefore tested whether the effects of neuronostatin also were dependent upon central oxytocin receptors. Neuronostatin-induced anorexia was not reversed by pretreatment with the oxytocin receptor antagonist, OVT, suggesting that neuronostatin acts through a unique subset of POMC neurons that do not signal via central oxytocin receptors. © 2010 Elsevier Inc. All rights reserved.
Recommended Citation
G. L. Yosten and W. K. Samson, "The Melanocortins, not Oxytocin, Mediate the Anorexigenic and Antidipsogenic Effects of Neuronostatin," Peptides, vol. 31, no. 9, pp. 1711 - 1714, Elsevier, Sep 2010.
The definitive version is available at https://doi.org/10.1016/j.peptides.2010.06.017
Department(s)
Biological Sciences
Keywords and Phrases
Appetite; Melanocortins; Neuronostatin; Oxytocin
International Standard Serial Number (ISSN)
0196-9781
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
01 Sep 2010
PubMed ID
20600426
Comments
National Institutes of Health, Grant 5T32GM008306