Muscarinic Receptors: Autonomic Neurons

Abstract

Muscarinic receptors bind acetylcholine to transduce signals in the central nervous system, autonomic ganglia, smooth muscles, and parasympathetic organs. the five closely related receptor subtypes (M1-M5) are members of the class a (rhodopsin-like) superfamily of G-protein-coupled receptors. These receptors possess seven membrane-spanning domains and specific sites for glycosylation, phosphorylation, lipid modification, and interaction with heterotrimeric transducer G-proteins. M1, M3, and M5 receptors are efficiently coupled through Gq/11 proteins to phospholipase Cβ, producing the second messengers diacylglycerol and inositol triphosphate. M2 and M4 receptors inhibit adenylate cyclase through actions involving Gi. Our understanding of muscarinic systems has advanced by analysis of receptor gene knockouts. © 2009 Elsevier Ltd All rights reserved.

Department(s)

Biological Sciences

Keywords and Phrases

Acetylcholine; Adenylate cyclase; Allosteric receptor regulation; Atropine; Cholinergic; G-protein-coupled receptor; Muscarinic receptor; Parasympathetic nervous system; Phospholipase C; Signal transduction; Synaptic transmission

International Standard Book Number (ISBN)

978-008045046-9

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2024 Elsevier, All rights reserved.

Publication Date

01 Jan 2009

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