Effects of Some Sulfur-containing Antioxidants on Lead-exposed Lenses
Lead (Pb) is known to negatively affect glutathione (GSH) metabolism in the lens. The present study examined the effects of Captopril, Taurine, and α-Lipoic acid on the Pb-induced GSH depletion and lipid peroxide increase in the lenticular system. Captopril administration returned the GSH, cysteine (CYS), and malondialdehyde (MDA) levels to near normal. Following Taurine administration the GSH, CYS and MDA levels were intermediate between the control group and the Pb group levels. α-Lipoic acid administration, however, only increased the CYS levels. No significant changes in oxidized glutathione (GSSG) levels were observed in any treatment group.
R. Neal et al., "Effects of Some Sulfur-containing Antioxidants on Lead-exposed Lenses," Free Radical Biology and Medicine, Elsevier, Jan 1999.
The definitive version is available at http://dx.doi.org/10.1016/S0891-5849(98)00214-7
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