Title

166Holmium-Containing Glass for Internal Radiotherapy of Tumors

Abstract

Aluminosilicate glass containing the β-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166Ho glass (200 μ Ci/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense β- radiation for localized internal radiotherapy of tumors.

Department(s)

Biological Sciences

Second Department

Materials Science and Engineering

Keywords and Phrases

glass; holmium 166; unclassified drug; DNA; radioisotope; animal experiment; breast carcinoma; cancer cell culture; cancer graft; controlled study; female; human cell; interstitial radiation; nude mouse; animal; brachytherapy; breast tumor; cancer transplantation; cell survival; metabolism; radiation exposure; Brachytherapy; Breast Neoplasms

International Standard Serial Number (ISSN)

8832897

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 1991 Elsevier, All rights reserved.

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