166Holmium-containing Glass for Internal Radiotherapy of Tumors
Aluminosilicate glass containing the beta-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 microns fragments of 166Ho glass (200 microCi/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense beta- radiation for localized internal radiotherapy of tumors.
R. F. Brown et al., "166Holmium-containing Glass for Internal Radiotherapy of Tumors," International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Elsevier, Jan 1991.
Materials Science and Engineering
Article - Journal
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