166Holmium-Containing Glass for Internal Radiotherapy of Tumors
Aluminosilicate glass containing the β-emitter 166Ho was tested for tumor cell killing effectiveness with the BT-20 human mammary carcinoma cell line as a model. Incubation of BT-20 cells with 166Ho glass partially inhibited DNA replication and completely blocked growth in cells located within 1.0 mm of the radioactive fiber. Growth of BT-20 tumor xenografts in nude mice was dramatically inhibited by injection of 2-5 μm fragments of 166Ho glass (200 μ Ci/tumor). The results suggest that 166Ho glass would be an effective modality for deposition of intense β- radiation for localized internal radiotherapy of tumors.
R. F. Brown et al., "166Holmium-Containing Glass for Internal Radiotherapy of Tumors," International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, vol. 18, no. 7, pp. 783-790, Elsevier, Jan 1991.
The definitive version is available at http://dx.doi.org/10.1016/0883-2897(91)90018-G
Materials Science and Engineering
Keywords and Phrases
glass; holmium 166; unclassified drug; DNA; radioisotope; animal experiment; breast carcinoma; cancer cell culture; cancer graft; controlled study; female; human cell; interstitial radiation; nude mouse; animal; brachytherapy; breast tumor; cancer transplantation; cell survival; metabolism; radiation exposure; Brachytherapy; Breast Neoplasms
International Standard Serial Number (ISSN)
Article - Journal
© 1991 Elsevier, All rights reserved.