Department

Chemical and Biochemical Engineering

Major

Chemical Engineering with Biochemical emphasis

Research Advisor

Yang, Hu

Advisor's Department

Chemical and Biochemical Engineering

Funding Source

Dr. Yang's Lab

Abstract

In a previous project it was determined ALC polarized lipid nanoparticles have a high transfection efficiency in some lung cancer cell lines. Building off this information, these ALC particles will now be tested with an actual lung cancer drug. This process will consist of searching articles for promising lung cancer drugs and selecting one for use. The ALC particles will then undergo a comprehensive drug study using multiple lung cancer cell lines with the selected drug. Aspects such as drug release rate, transfection rate, cytotoxicity, etc. will be determined. The goal is to determine whether ALC nanoparticles show real promise in the field of cancer drug delivery. Hopefully this project will help me to gain insight into drug studies and even show a potential treatment for lung cancer cells.

Biography

Noah Sparks is a senior Chemical engineering student with a passion for research. He has worked in Dr. Yang's lab since freshman year and had DURE projects with them for the past two years. He is a hardworking student who works to maintain good grades, while getting experience within the lab. He hopes to work in the biochemical research field and believes undergraduate research will give him the experience necessary to thrive in the field.

Research Category

Engineering

Presentation Type

OURE Fellows Proposal Oral Applicant

Document Type

Poster

Location

Innovation Forum - 1st Floor Innovation Lab

Presentation Date

10 April 2024, 1:00 pm - 4:00 pm

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Apr 10th, 1:00 PM Apr 10th, 4:00 PM

Lung Cancer Drug Study using ALC Nanoparticles

Innovation Forum - 1st Floor Innovation Lab

In a previous project it was determined ALC polarized lipid nanoparticles have a high transfection efficiency in some lung cancer cell lines. Building off this information, these ALC particles will now be tested with an actual lung cancer drug. This process will consist of searching articles for promising lung cancer drugs and selecting one for use. The ALC particles will then undergo a comprehensive drug study using multiple lung cancer cell lines with the selected drug. Aspects such as drug release rate, transfection rate, cytotoxicity, etc. will be determined. The goal is to determine whether ALC nanoparticles show real promise in the field of cancer drug delivery. Hopefully this project will help me to gain insight into drug studies and even show a potential treatment for lung cancer cells.