Cellular Hitchhiking of Nanoparticles
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Barua, Sutapa
Advisor's Department
Chemical and Biochemical Engineering
Funding Source
PI's Start Up and Ozark Biomedical Initiative
Abstract
The overall goal of the research is to explore a combinatorial approach in exploiting the specificity of antibody conjugated drug Nano rods with the direction of polyclonal T cells for breast cancer therapy. Nanoparticles are increasingly appearing as a promising tool for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. Most applications of nanotechnology in drug delivery have focused on improving blood circulation half-lives, or targeting the cancer tissue. However there are challenges to deliver nanoparticles and their payloads into a tumor parenchyma even after they reach the tumor sites. To address this issue, the research will target the drug nanoparticles for an efficient delivery of therapeutic payloads to the breast cancer site, and expand therapeutic benefits. We hypothesize that the attachment of Trastuzumab-conjugated paclitaxel drug Nano rods to natural T cells will enhance their circulation time and substantially alter their anti-tumoral efficacy.
Biography
Kaitlyne Powers is a senior at Missouri University of Science and Technology pursuing a B.S. in Chemical Engineering. She transferred from the University of Missouri St Louis to Missouri S&T in the fall of 2017 to obtain a chemical engineering degree. She wants to work for the pharmaceutical field once she graduates in May 2020 and the undergraduate research Kaitlyne is in is preparing her for that field. The research is giving Kaitlyne hands on experience that she can utilize before graduating to apply to her field of work.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Award
Engineering oral presentation, Third place
Location
Ozark Room
Presentation Date
16 Apr 2019, 1:00 pm - 1:30 pm
Cellular Hitchhiking of Nanoparticles
Ozark Room
The overall goal of the research is to explore a combinatorial approach in exploiting the specificity of antibody conjugated drug Nano rods with the direction of polyclonal T cells for breast cancer therapy. Nanoparticles are increasingly appearing as a promising tool for non-invasive and targeted delivery of therapeutic agents to breast tumor tissues. Most applications of nanotechnology in drug delivery have focused on improving blood circulation half-lives, or targeting the cancer tissue. However there are challenges to deliver nanoparticles and their payloads into a tumor parenchyma even after they reach the tumor sites. To address this issue, the research will target the drug nanoparticles for an efficient delivery of therapeutic payloads to the breast cancer site, and expand therapeutic benefits. We hypothesize that the attachment of Trastuzumab-conjugated paclitaxel drug Nano rods to natural T cells will enhance their circulation time and substantially alter their anti-tumoral efficacy.
