Title

DNA Decorated Multifunctional Gold Nanoparticles

Presenter Information

Rachel Nixon

Department

Chemistry

Major

Chemistry

Research Advisor

Wang, Risheng

Advisor's Department

Chemistry

Funding Source

Department of Chemistry; OURE

Abstract

Gold nanoparticles have attracted extensive research interests due to their unique optical, electrical, and physical properties. The hybridization of gold nanoparticles, along with other nanomaterials, has stimulated applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of gold nanoparticles with precisely controlled distance and orientation remains difficult in nanotechnology fields. This challenge can be overcome by using DNA origami scaffolding as templates. One such method of organization is by anchoring the nanoparticles, which are functionalized with single-stranded DNA, to a twodimensional DNA origami tile surface via DNA hybridization. In this work, multi-functionalized gold nanoparticles were developed to determine the effect of nanoparticle coating composition on binding efficiency at two separate anchor sites of a DNA origami template. The ratio of coated DNA sequences as well as the functional strand length were varied to elucidate their influences on gold nanoparticle-conjugate functionality and stability.

Biography

Rachel Nixon is a sophomore pursuing a degree in Chemistry with a minor in Mathematics. She is an active member of the Honors Academy, the W. T. Schrenk student chapter of the American Chemical Society, and the Missouri S&T Symphonic Band. She has worked on projects investigating DNA nanotechnology under the direction of Dr. Risheng Wang since April 2017, and plans to continue her education in chemistry through graduate studies.

Research Category

Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium

Presentation Date

17 Apr 2018, 9:00 am - 12:00 pm

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Apr 17th, 9:00 AM Apr 17th, 12:00 PM

DNA Decorated Multifunctional Gold Nanoparticles

Upper Atrium

Gold nanoparticles have attracted extensive research interests due to their unique optical, electrical, and physical properties. The hybridization of gold nanoparticles, along with other nanomaterials, has stimulated applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of gold nanoparticles with precisely controlled distance and orientation remains difficult in nanotechnology fields. This challenge can be overcome by using DNA origami scaffolding as templates. One such method of organization is by anchoring the nanoparticles, which are functionalized with single-stranded DNA, to a twodimensional DNA origami tile surface via DNA hybridization. In this work, multi-functionalized gold nanoparticles were developed to determine the effect of nanoparticle coating composition on binding efficiency at two separate anchor sites of a DNA origami template. The ratio of coated DNA sequences as well as the functional strand length were varied to elucidate their influences on gold nanoparticle-conjugate functionality and stability.