DNA Decorated Multifunctional Gold Nanoparticles
Department
Chemistry
Major
Chemistry
Research Advisor
Wang, Risheng
Advisor's Department
Chemistry
Funding Source
Department of Chemistry; OURE
Abstract
Gold nanoparticles have attracted extensive research interests due to their unique optical, electrical, and physical properties. The hybridization of gold nanoparticles, along with other nanomaterials, has stimulated applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of gold nanoparticles with precisely controlled distance and orientation remains difficult in nanotechnology fields. This challenge can be overcome by using DNA origami scaffolding as templates. One such method of organization is by anchoring the nanoparticles, which are functionalized with single-stranded DNA, to a twodimensional DNA origami tile surface via DNA hybridization. In this work, multi-functionalized gold nanoparticles were developed to determine the effect of nanoparticle coating composition on binding efficiency at two separate anchor sites of a DNA origami template. The ratio of coated DNA sequences as well as the functional strand length were varied to elucidate their influences on gold nanoparticle-conjugate functionality and stability.
Biography
Rachel Nixon is a sophomore pursuing a degree in Chemistry with a minor in Mathematics. She is an active member of the Honors Academy, the W. T. Schrenk student chapter of the American Chemical Society, and the Missouri S&T Symphonic Band. She has worked on projects investigating DNA nanotechnology under the direction of Dr. Risheng Wang since April 2017, and plans to continue her education in chemistry through graduate studies.
Research Category
Sciences
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium
Presentation Date
17 Apr 2018, 9:00 am - 12:00 pm
DNA Decorated Multifunctional Gold Nanoparticles
Upper Atrium
Gold nanoparticles have attracted extensive research interests due to their unique optical, electrical, and physical properties. The hybridization of gold nanoparticles, along with other nanomaterials, has stimulated applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization of gold nanoparticles with precisely controlled distance and orientation remains difficult in nanotechnology fields. This challenge can be overcome by using DNA origami scaffolding as templates. One such method of organization is by anchoring the nanoparticles, which are functionalized with single-stranded DNA, to a twodimensional DNA origami tile surface via DNA hybridization. In this work, multi-functionalized gold nanoparticles were developed to determine the effect of nanoparticle coating composition on binding efficiency at two separate anchor sites of a DNA origami template. The ratio of coated DNA sequences as well as the functional strand length were varied to elucidate their influences on gold nanoparticle-conjugate functionality and stability.
