Heteromer Stars for the Treatment of Breast Cancer
Department
Chemical and Biochemical Engineering
Major
Biochemical Engineering
Research Advisor
Barua, Sutapa
Advisor's Department
Chemical and Biochemical Engineering
Funding Source
Start Up of Dr. Barua; OURE Program
Abstract
A star-like structure has potential to carry large quantities of a therapeutic agent, improve adherence to target cells and safely release drugs after prolonged period of residence at the diseased site. However, synthesis of such a stellate structure is not an easy task. Here, the design of a polylactide-co-glycolic acid (PLGA) based star shape conformation is described for the treatment of breast cancer. About 1 in 8 U.S. women (12%) develops invasive breast cancer over the course of her lifetime. In 2016, an estimated 246,660 new cases of invasive breast cancer were expected to be diagnosed in women in the U.S., along with 61,000 new cases of non-invasive (in situ) breast cancer. Although a variety of nanoparticles have been tested in lab scale, the use of heteromer armed nanoparticles presents a unique drug release matrix. PLGA is a biocompatible polymer that enables controlled release of tetrakis(hydroxymethyl) phosphonium chloride (THPC) drugs into breast cancer cells. This novel delivery platform significantly inhibits the breast cancer cell growth population that potentiates the efficacy of THPC treatment.
Biography
Caitlin Brocker is a senior and will complete her B.S. in Chemical Engineering with a Biochemical Emphasis at Missouri University of Science and Technology in May. Caitlin is also on the Missouri S&T Women’s Volleyball Team and the Love Your Melon Campus Crew. She has been working in Dr. Sutapa Barua’s lab since April 2015, and her projects have involved drug delivery systems for breast cancer treatment. Caitlin has published one paper in the journal Nanotechnology (impact factor = 3.573) in 2017 and is preparing one more that will be submitted in 2017. She won 3rd place in the Engineering oral presentation in the 2016 OURE research meeting.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Award
Engineering oral presentation, Second place
Location
Missouri Room
Presentation Date
11 Apr 2017, 9:30 am - 10:00 am
Heteromer Stars for the Treatment of Breast Cancer
Missouri Room
A star-like structure has potential to carry large quantities of a therapeutic agent, improve adherence to target cells and safely release drugs after prolonged period of residence at the diseased site. However, synthesis of such a stellate structure is not an easy task. Here, the design of a polylactide-co-glycolic acid (PLGA) based star shape conformation is described for the treatment of breast cancer. About 1 in 8 U.S. women (12%) develops invasive breast cancer over the course of her lifetime. In 2016, an estimated 246,660 new cases of invasive breast cancer were expected to be diagnosed in women in the U.S., along with 61,000 new cases of non-invasive (in situ) breast cancer. Although a variety of nanoparticles have been tested in lab scale, the use of heteromer armed nanoparticles presents a unique drug release matrix. PLGA is a biocompatible polymer that enables controlled release of tetrakis(hydroxymethyl) phosphonium chloride (THPC) drugs into breast cancer cells. This novel delivery platform significantly inhibits the breast cancer cell growth population that potentiates the efficacy of THPC treatment.
