Angiogenic Effects of Mesenchymal Stem Cells and Bioglass on Chick CAM Vasculature
Department
Biological Sciences
Major
Biology
Research Advisor
Semon, Julie A.
Advisor's Department
Biological Sciences
Funding Source
Seed Grant from Center for Biomedical Sciences and Engineering
Abstract
New blood vessels are generated through a physiological process called angiogenesis. Formation of these blood vessels comes primarily from pre-existing vasculature. Using a chick chorioallantoic membrane (CAM), which provides a highly vascularized animal model, adipose- and bone marrow-derived mesenchymal stem cells and borate-based 13-93B3 bioglass were tested for angiogenic properties. The mesenchymal stem cells (MSC) and the borate bioglass were expected to accelerate angiogenesis within the CAM model. MSCs and bioglass were carefully placed between major blood vessels in the chick embryos seven days after their eggs were cracked. Angiogenesis was observed on a daily basis for three consecutive days before using a dissecting scope to capture images of vasculature in and around the plastic rings. Images were then analyzed and individual vasculature comparisons were made among: adipose derived-MSCs (AD-MSCs), bone marrow derived-MSCs (BM-MSCs), bioglass incorporated with AD-MSCs, and bioglass incorporated with BM-MSCs.
Biography
Daniel Park is a second bachelor’s degree student majoring in biology. After completing his economics degree at Emory University in 2013, Daniel decided to study a subject that catered more to his interests and career goals. While working in Dr. Julie Semon’s Regenerative Medicine Lab, Daniel has only become more enthusiastic about the biological sciences and the research being done in the field of stem cells.
Research Category
Research Proposals
Presentation Type
Poster Presentation
Document Type
Poster
Award
Sciences poster session, First place
Location
Upper Atrium/Hallway
Presentation Date
11 Apr 2016, 9:00 am - 11:45 am
Angiogenic Effects of Mesenchymal Stem Cells and Bioglass on Chick CAM Vasculature
Upper Atrium/Hallway
New blood vessels are generated through a physiological process called angiogenesis. Formation of these blood vessels comes primarily from pre-existing vasculature. Using a chick chorioallantoic membrane (CAM), which provides a highly vascularized animal model, adipose- and bone marrow-derived mesenchymal stem cells and borate-based 13-93B3 bioglass were tested for angiogenic properties. The mesenchymal stem cells (MSC) and the borate bioglass were expected to accelerate angiogenesis within the CAM model. MSCs and bioglass were carefully placed between major blood vessels in the chick embryos seven days after their eggs were cracked. Angiogenesis was observed on a daily basis for three consecutive days before using a dissecting scope to capture images of vasculature in and around the plastic rings. Images were then analyzed and individual vasculature comparisons were made among: adipose derived-MSCs (AD-MSCs), bone marrow derived-MSCs (BM-MSCs), bioglass incorporated with AD-MSCs, and bioglass incorporated with BM-MSCs.
