Title

Fabrication and evaluation of polylactide/bioactive glass composites for tissue engineering applications

Presenter Information

Shayan Sazdar

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Day, D. E.
Mohammadkhah, Ali

Advisor's Department

Materials Science and Engineering

Funding Source

Missouri University of Science and Technology

Abstract

Recent research in the field of bioactive glasses has shown that bioactive borate glasses hold strong potential as materials for tissue engineering in the areas of angiogenesis and potentially even nerve repair. The focus of the present work was to develop and evaluate flexible polymer/bioactive glass composite films for tissue engineering applications such as repairing peripheral nerves. Polylactide (PLA) composites containing up to 50 weight percent of bioactive borate and/or silicate glass particles (approximately 20 μm in diameter) were fabricated by solvent casting. The dried composites were then immersed in static simulated body fluid (SBF) at 37⁰C for 23 days during which time the degradation of the different composites was analyzed based on the amount of ions released from the bioactive glass. The favorable degradation characteristics of the composites indicated that the PLA/bioactive glass composites have potential to act as conduits for repairing damaged nerves.

Biography

Shayan Sazdar is currently a sophomore in chemical engineering from Chesterfield, Missouri. He has been working with Dr. Delbert Day’s research group at the Missouri S&T Materials Research Center since the fall of 2013 and worked with Dr. Susan Stagg-Williams and Dr. Michael Detamore at the University of Kansas Department of Chemical and Petroleum Engineering on biofuels and tissue engineering research during the summer of 2014. Shayan is also a member and a former officer of the Missouri S&T Chem-E-Car Design Team and the Missouri S&T Student Chapter of the American Institute of Chemical Engineers.

Research Category

Engineering

Presentation Type

Oral Presentation

Document Type

Presentation

Location

St. Pat's B

Presentation Date

15 Apr 2015, 10:30 am - 11:00 am

This document is currently not available here.

Share

COinS
 
Apr 15th, 10:30 AM Apr 15th, 11:00 AM

Fabrication and evaluation of polylactide/bioactive glass composites for tissue engineering applications

St. Pat's B

Recent research in the field of bioactive glasses has shown that bioactive borate glasses hold strong potential as materials for tissue engineering in the areas of angiogenesis and potentially even nerve repair. The focus of the present work was to develop and evaluate flexible polymer/bioactive glass composite films for tissue engineering applications such as repairing peripheral nerves. Polylactide (PLA) composites containing up to 50 weight percent of bioactive borate and/or silicate glass particles (approximately 20 μm in diameter) were fabricated by solvent casting. The dried composites were then immersed in static simulated body fluid (SBF) at 37⁰C for 23 days during which time the degradation of the different composites was analyzed based on the amount of ions released from the bioactive glass. The favorable degradation characteristics of the composites indicated that the PLA/bioactive glass composites have potential to act as conduits for repairing damaged nerves.