Fabrication and evaluation of polylactide/bioactive glass composites for tissue engineering applications
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Day, D. E.
Mohammadkhah, Ali
Advisor's Department
Materials Science and Engineering
Funding Source
Missouri University of Science and Technology
Abstract
Recent research in the field of bioactive glasses has shown that bioactive borate glasses hold strong potential as materials for tissue engineering in the areas of angiogenesis and potentially even nerve repair. The focus of the present work was to develop and evaluate flexible polymer/bioactive glass composite films for tissue engineering applications such as repairing peripheral nerves. Polylactide (PLA) composites containing up to 50 weight percent of bioactive borate and/or silicate glass particles (approximately 20 μm in diameter) were fabricated by solvent casting. The dried composites were then immersed in static simulated body fluid (SBF) at 37⁰C for 23 days during which time the degradation of the different composites was analyzed based on the amount of ions released from the bioactive glass. The favorable degradation characteristics of the composites indicated that the PLA/bioactive glass composites have potential to act as conduits for repairing damaged nerves.
Biography
Shayan Sazdar is currently a sophomore in chemical engineering from Chesterfield, Missouri. He has been working with Dr. Delbert Day’s research group at the Missouri S&T Materials Research Center since the fall of 2013 and worked with Dr. Susan Stagg-Williams and Dr. Michael Detamore at the University of Kansas Department of Chemical and Petroleum Engineering on biofuels and tissue engineering research during the summer of 2014. Shayan is also a member and a former officer of the Missouri S&T Chem-E-Car Design Team and the Missouri S&T Student Chapter of the American Institute of Chemical Engineers.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Location
St. Pat's B
Presentation Date
15 Apr 2015, 10:30 am - 11:00 am
Fabrication and evaluation of polylactide/bioactive glass composites for tissue engineering applications
St. Pat's B
Recent research in the field of bioactive glasses has shown that bioactive borate glasses hold strong potential as materials for tissue engineering in the areas of angiogenesis and potentially even nerve repair. The focus of the present work was to develop and evaluate flexible polymer/bioactive glass composite films for tissue engineering applications such as repairing peripheral nerves. Polylactide (PLA) composites containing up to 50 weight percent of bioactive borate and/or silicate glass particles (approximately 20 μm in diameter) were fabricated by solvent casting. The dried composites were then immersed in static simulated body fluid (SBF) at 37⁰C for 23 days during which time the degradation of the different composites was analyzed based on the amount of ions released from the bioactive glass. The favorable degradation characteristics of the composites indicated that the PLA/bioactive glass composites have potential to act as conduits for repairing damaged nerves.
