E.coli Administration of GLP1 in the Presence of Glucose
Department
Biological Sciences
Major
Biological Sciences
Research Advisor
Westenberg, David J.
Shannon, Katie
Advisor's Department
Biological Sciences
Abstract
Glucagon like peptide 1 (GLP1) has been used in recent studies as an experimental treatment for Type 2 diabetes. Type 2 diabetes is characterized by low insulin production of beta cells in the pancreas coupled with insulin resistance in muscle, liver, and fat cells. Patients with type 2 diabetes usually have to take medications that decrease sugar up take and/or increase insulin production. My project proposal uses synthetic biology to induce E.coli bacteria to create GLP1 in the presence of glucose. GLP1 is a naturally occurring chemical in the body. I predict, in the presence of glucose, E.coli will produce GLP1 and the resulting reactions when GLP1 binds to GLP1 receptors will stimulate the proliferation of beta cells and also induce existing beta cells to create insulin. E.coli was chosen because it already exists in human gut flora and is easy to manipulate using a lac operon repressor.
Biography
Anamaria is a senior majoring in Biological Sciences. In addition to this project proposal, she is also participating in undergraduate research with Dr. Ercal. The research she is involved in is looking into an experimental ultrasound delivery system of eye drug administration to rats. On and off campus Anamaria is involved with many organizations to include The Missouri Miner as the Photo and Entertainment editor, Military Aerospace Society, Blue Sabres, and Civil Air Patrol. As a student she also works part time at The Center as a lifeguard and as a Red Cross Lifeguard Instructor. Anamaria will be graduating this upcoming May with a Bachelor's of Science degree. Upon graduation she will join the United States Air Force as a 2nd Lieutenant and station in Colorado Springs at Schriever AFB as a Space Operations Officer.
Research Category
Research Proposals
Presentation Type
Poster Presentation
Document Type
Poster
Award
Research proposal poster session, First place
Location
Upper Atrium/Hallway
Presentation Date
03 Apr 2013, 1:00 pm - 3:00 pm
E.coli Administration of GLP1 in the Presence of Glucose
Upper Atrium/Hallway
Glucagon like peptide 1 (GLP1) has been used in recent studies as an experimental treatment for Type 2 diabetes. Type 2 diabetes is characterized by low insulin production of beta cells in the pancreas coupled with insulin resistance in muscle, liver, and fat cells. Patients with type 2 diabetes usually have to take medications that decrease sugar up take and/or increase insulin production. My project proposal uses synthetic biology to induce E.coli bacteria to create GLP1 in the presence of glucose. GLP1 is a naturally occurring chemical in the body. I predict, in the presence of glucose, E.coli will produce GLP1 and the resulting reactions when GLP1 binds to GLP1 receptors will stimulate the proliferation of beta cells and also induce existing beta cells to create insulin. E.coli was chosen because it already exists in human gut flora and is easy to manipulate using a lac operon repressor.
