Is Hof1 a Dbf2 Target?
Department
Biological Sciences
Major
Biology
Research Advisor
Shannon, Katie
Advisor's Department
Biological Sciences
Funding Source
Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program
Abstract
Hof1 is a member of the Pombe Cdc15 homology (PCH) family, a conserved family of genes involved in cytokinesis in yeast and mammalian cells. Cytokinesis is the physical separation of one cell into two, accomplished by contraction of a ring composed of Factin and type II myosin. In budding yeast, Hof1 is required for normal contraction of the actomyosin ring and accompanying septum deposition. The phosphorylation of Hof1 during mitosis has been shown to be mitotic exit network (MEN) dependent. The goal of this study is to show if Hof1 is a target of the MEN kinase, Dbf2.
Biography
Benjamin Hale is at his fourth and final year at Missouri University of Science and Technology. He has done two prior OURE’s in environmental microbiology, has been employed as a research assistant on campus, and participated in a summer research internship through Iowa State University Interdepartmental Genetics Program.
Research Category
Sciences
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium/Hallway
Presentation Date
07 Apr 2010, 9:00 am - 11:45 am
Is Hof1 a Dbf2 Target?
Upper Atrium/Hallway
Hof1 is a member of the Pombe Cdc15 homology (PCH) family, a conserved family of genes involved in cytokinesis in yeast and mammalian cells. Cytokinesis is the physical separation of one cell into two, accomplished by contraction of a ring composed of Factin and type II myosin. In budding yeast, Hof1 is required for normal contraction of the actomyosin ring and accompanying septum deposition. The phosphorylation of Hof1 during mitosis has been shown to be mitotic exit network (MEN) dependent. The goal of this study is to show if Hof1 is a target of the MEN kinase, Dbf2.
