Drugs Associated with Fatal Cutaneous Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Department
Biological Sciences
Major
Chemical Engineering
Research Advisor
Stoecker, William V.
Advisor's Department
Electrical and Computer Engineering
Funding Source
Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Fellows Program; DERMVIS Research Group
Abstract
Two severe drug reactions, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were analyzed using the FDA’s Adverse Events Reporting System’s (AERS) drug reports from 2004 to 2008. Drugs were identified as being at risk by analyzing the number of reported cases of SJS and TEN with serious and fatal outcomes for drugs with a significant proportional relative risk (PRR > 2.0). The study resulted in the discovery of primary suspect drugs in the top ten list of fatal outcome SJS-TEN cases. These drugs were not previously suspected to have significant SJSTEN risk. The drugs include furosemide (PRR=6.6), ciprofloxacin (PRR=5.6), and ibuprofen (PRR=5.8). The data gathered from this study could be duplicated for other serious drug reaction leading to serious outcomes and death and made available to physicians through an online database.
Biography
John Krumme is a senior at Missouri S&T majoring in Chemical Engineering with a minor in Biological Science. Along with working with the DERMVIS, Krumme is active on campus as a student-athlete on the Miner’s Men’s Football Team, served as the president of Tau Beta Pi, participated as an active member of the school’s pre-medical society (SCRUBS), and is an active member of Sigma Phi Epsilon. Krumme is also a member of the Mentoring Makes a Difference outreach program put on by Prevention Consultants for Missouri. Krumme will graduate in May, 2010, and will attend medical school in August at the University of Missouri.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Location
Gasconade Room
Presentation Date
07 Apr 2010, 10:30 am - 11:00 am
Drugs Associated with Fatal Cutaneous Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Gasconade Room
Two severe drug reactions, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were analyzed using the FDA’s Adverse Events Reporting System’s (AERS) drug reports from 2004 to 2008. Drugs were identified as being at risk by analyzing the number of reported cases of SJS and TEN with serious and fatal outcomes for drugs with a significant proportional relative risk (PRR > 2.0). The study resulted in the discovery of primary suspect drugs in the top ten list of fatal outcome SJS-TEN cases. These drugs were not previously suspected to have significant SJSTEN risk. The drugs include furosemide (PRR=6.6), ciprofloxacin (PRR=5.6), and ibuprofen (PRR=5.8). The data gathered from this study could be duplicated for other serious drug reaction leading to serious outcomes and death and made available to physicians through an online database.
Comments
Joint project with Thomas McKinnon