Title

Photopatternable Hydrogel Membranes for Fluorescence Based Glucose Biosensors

Presenter Information

Morgan Boresi

Department

Chemical and Biochemical Engineering

Major

Chemical Engineering

Research Advisor

Henthorn, David
Kim, Chang-Soo

Advisor's Department

Chemical and Biochemical Engineering

Second Advisor's Department

Electrical and Computer Engineering

Funding Source

Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program

Abstract

With the increasing number of people succumbing to diabetes, a painless, implantable and continuous glucose sensor would be an asset in the measurement and correction cycle paramount to the management of this disease. In this work, a hydrogen peroxide sensitive fluorophore called europium tetracycline (EuTc) was incorporated into a photopatternable hydrogel matrix. EuTc can form a reversible complex with hydrogen peroxide making it suited for long term sensitivity. Hydrogen peroxide is a byproduct of the enzymatic oxidation of glucose in the presence of glucose oxidase. By utilizing the fluorescent intensity resulting from hydrogen peroxide production, glucose levels can be indirectly determined.

Biography

Morgan Boresi is a junior earning her degree in Chemical Engineering with an emphasis in Biology and minors in Biology and Psychology Neuroscience. She works in Dr. David Henthorn’s laboratory as an OURE student. Outside of research she participates in several student organizations including Kappa Delta Sorority and Panhellenic Council.

Research Category

Engineering

Presentation Type

Poster Presentation

Document Type

Poster

Location

Upper Atrium/Hallway

Presentation Date

08 Apr 2009, 1:00 pm - 3:00 pm

Comments

Joint project with Christian Pick

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Apr 8th, 1:00 PM Apr 8th, 3:00 PM

Photopatternable Hydrogel Membranes for Fluorescence Based Glucose Biosensors

Upper Atrium/Hallway

With the increasing number of people succumbing to diabetes, a painless, implantable and continuous glucose sensor would be an asset in the measurement and correction cycle paramount to the management of this disease. In this work, a hydrogen peroxide sensitive fluorophore called europium tetracycline (EuTc) was incorporated into a photopatternable hydrogel matrix. EuTc can form a reversible complex with hydrogen peroxide making it suited for long term sensitivity. Hydrogen peroxide is a byproduct of the enzymatic oxidation of glucose in the presence of glucose oxidase. By utilizing the fluorescent intensity resulting from hydrogen peroxide production, glucose levels can be indirectly determined.