Photopatternable Hydrogel Membranes for Fluorescence Based Glucose Biosensors
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Henthorn, David
Kim, Chang-Soo
Advisor's Department
Chemical and Biochemical Engineering
Second Advisor's Department
Electrical and Computer Engineering
Funding Source
Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program
Abstract
With the increasing number of people succumbing to diabetes, a painless, implantable and continuous glucose sensor would be an asset in the measurement and correction cycle paramount to the management of this disease. In this work, a hydrogen peroxide sensitive fluorophore called europium tetracycline (EuTc) was incorporated into a photopatternable hydrogel matrix. EuTc can form a reversible complex with hydrogen peroxide making it suited for long term sensitivity. Hydrogen peroxide is a byproduct of the enzymatic oxidation of glucose in the presence of glucose oxidase. By utilizing the fluorescent intensity resulting from hydrogen peroxide production, glucose levels can be indirectly determined.
Biography
Morgan Boresi is a junior earning her degree in Chemical Engineering with an emphasis in Biology and minors in Biology and Psychology Neuroscience. She works in Dr. David Henthorn’s laboratory as an OURE student. Outside of research she participates in several student organizations including Kappa Delta Sorority and Panhellenic Council.
Research Category
Engineering
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium/Hallway
Presentation Date
08 Apr 2009, 1:00 pm - 3:00 pm
Photopatternable Hydrogel Membranes for Fluorescence Based Glucose Biosensors
Upper Atrium/Hallway
With the increasing number of people succumbing to diabetes, a painless, implantable and continuous glucose sensor would be an asset in the measurement and correction cycle paramount to the management of this disease. In this work, a hydrogen peroxide sensitive fluorophore called europium tetracycline (EuTc) was incorporated into a photopatternable hydrogel matrix. EuTc can form a reversible complex with hydrogen peroxide making it suited for long term sensitivity. Hydrogen peroxide is a byproduct of the enzymatic oxidation of glucose in the presence of glucose oxidase. By utilizing the fluorescent intensity resulting from hydrogen peroxide production, glucose levels can be indirectly determined.
Comments
Joint project with Christian Pick