Cytokinesis Defects in Budding Yeast
Department
Biological Sciences
Major
Biological Sciences
Research Advisor
Shannon, Katie
Advisor's Department
Biological Sciences
Funding Source
Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program
Abstract
Budding yeast are a very good research organism, because they are similar to humans in many ways. One of the research opportunities with budding yeast is that there are many genes that are uncharacterized, and it is not known what their cellular function is or what their functional role is. There are also many genes that are affected by phosphorylation, one such gene is HOF1. Hof1 is phosphorylated during mitosis and results have shown that a Hof1 mutant without a PEST domain affects Hof1-GFP dynamics during cytokinesis. It has also been shown that deletion of the PEST domain may prevent phosphorylation of Hof1 (Blondel et al., 2005). Cytokinesis is the division of a cell into two daughter cells. Our research lab is interested in cytokinesis, because cytokinesis defects can lead to polyploidy in the cell. This defect can lead to cancer or cell death.
Biography
Katherine Stockstill is a graduating senior majoring in Biological Sciences. On campus, Katherine is member Kappa Delta Sorority, Helix, and Phi Sigma. She also has an OURE for her research in the Cytokinesis Lab. Katherine is also a waitress at Applebee’s. After graduation Katherine is planning on going onto graduate school, where she will pursue a master’s degree.
Research Category
Sciences
Presentation Type
Oral Presentation
Document Type
Presentation
Award
Sciences oral presentation, Third place
Location
Turner Room
Presentation Date
08 Apr 2009, 10:00 am - 10:30 am
Cytokinesis Defects in Budding Yeast
Turner Room
Budding yeast are a very good research organism, because they are similar to humans in many ways. One of the research opportunities with budding yeast is that there are many genes that are uncharacterized, and it is not known what their cellular function is or what their functional role is. There are also many genes that are affected by phosphorylation, one such gene is HOF1. Hof1 is phosphorylated during mitosis and results have shown that a Hof1 mutant without a PEST domain affects Hof1-GFP dynamics during cytokinesis. It has also been shown that deletion of the PEST domain may prevent phosphorylation of Hof1 (Blondel et al., 2005). Cytokinesis is the division of a cell into two daughter cells. Our research lab is interested in cytokinesis, because cytokinesis defects can lead to polyploidy in the cell. This defect can lead to cancer or cell death.
