Title

Chemical modeling of Alcohol Metabolism, a field of major (and Miner) importance

Presenter Information

Tara Banaszek

Department

Chemistry

Major

Chemistry; Biological Sciences

Research Advisor

Sinn, Ekkehard

Advisor's Department

Chemistry

Abstract

The metabolism of short chain alcohols is a vital process for various organisms, not just ethanol consumers. Enzymes like galactose oxidase (GOase) promote this by catalyzing the oxidation of the alcohols to aldehydes. GOase has copper at the active site but differs from most copper enzymes in having just one copper atom instead of two. This project focuses on a specific group of alcohol oxidizing reagents synthesized of copper Schiff bases to make compounds that model the half-way point of the oxidation. This cannot be done with the enzymes themselves. The purpose of this project is to make and study various unique mononuclear copper complexes, in order to propose a mechanism by which the oxidation is possible.

Biography

Tara is double majoring in Chemistry (Biochem Emphasis) and Biological Sciences with a minor in Cognitive Neuroscience. She is involved in the W. T. Schrenk Society (President), ASUM (Executive Board Member), Zeta Tau Alpha (assistant treasurer), Blue Key Honor Society, Student Council, Honors Academy, and Psi Chi.

Research Category

Natural Sciences

Presentation Type

Poster Presentation

Document Type

Poster

Presentation Date

12 Apr 2006, 1:00 pm

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Apr 12th, 1:00 PM

Chemical modeling of Alcohol Metabolism, a field of major (and Miner) importance

The metabolism of short chain alcohols is a vital process for various organisms, not just ethanol consumers. Enzymes like galactose oxidase (GOase) promote this by catalyzing the oxidation of the alcohols to aldehydes. GOase has copper at the active site but differs from most copper enzymes in having just one copper atom instead of two. This project focuses on a specific group of alcohol oxidizing reagents synthesized of copper Schiff bases to make compounds that model the half-way point of the oxidation. This cannot be done with the enzymes themselves. The purpose of this project is to make and study various unique mononuclear copper complexes, in order to propose a mechanism by which the oxidation is possible.