Elution Characteristics of Teicoplanin-Loaded Biodegradable Borate Glass/Chitosan Composite
Local antibiotic delivery system has an advantage over systemic antibiotic for osteomyelitis treatment due to the delivery of high local antibiotic concentration while avoiding potential systemic toxicity. Composite biomaterials with multifunctional roles, consisting of a controlled antibiotic release, a mechanical (load-bearing) function, and the ability to promote bone regeneration, gradually become the most active area of investigation and development of local antibiotic delivery vehicles. In the present study, a composite of borate glass and chitosan (designated BG/C) was developed as teicoplanin delivery vehicle. The in vitro elution kinetics and antibacterial activity of teicoplanin released from BG/C composite as a function of immersion time were determined. Moreover, the pH changes of eluents and the bioactivity of the composite were characterized using scanning electron microscopy coupled with energy-dispersive spectroscopy and X-ray diffraction analysis.
W. Jia et al., "Elution Characteristics of Teicoplanin-Loaded Biodegradable Borate Glass/Chitosan Composite," International Journal of Pharmaceutics, vol. 387, no. 2020-01-02, pp. 194-186, Elsevier, Mar 2010.
The definitive version is available at https://doi.org/10.1016/j.ijpharm.2009.12.002
Nuclear Engineering and Radiation Science
Materials Science and Engineering
Shanghai Committee of Science and Technology
Keywords and Phrases
Biodegradability; Borate Glass/Chitosan Composite; Osteoconductivity; Teicoplanin; antibacterial activity; biodegradation; composite material; drug delivery system; drug release; elution; minimum inhibitory concentration; pH; scanning electron microscopy; surface property; sustained drug release; viscosity; X ray diffraction
International Standard Serial Number (ISSN)
Article - Journal
© 2010 Elsevier, All rights reserved.
01 Mar 2010