Elution Characteristics of Teicoplanin-Loaded Biodegradable Borate Glass/Chitosan Composite

Abstract

Local antibiotic delivery system has an advantage over systemic antibiotic for osteomyelitis treatment due to the delivery of high local antibiotic concentration while avoiding potential systemic toxicity. Composite biomaterials with multifunctional roles, consisting of a controlled antibiotic release, a mechanical (load-bearing) function, and the ability to promote bone regeneration, gradually become the most active area of investigation and development of local antibiotic delivery vehicles. In the present study, a composite of borate glass and chitosan (designated BG/C) was developed as teicoplanin delivery vehicle. The in vitro elution kinetics and antibacterial activity of teicoplanin released from BG/C composite as a function of immersion time were determined. Moreover, the pH changes of eluents and the bioactivity of the composite were characterized using scanning electron microscopy coupled with energy-dispersive spectroscopy and X-ray diffraction analysis.

Department(s)

Nuclear Engineering and Radiation Science

Second Department

Materials Science and Engineering

Sponsor(s)

Shanghai Committee of Science and Technology

Keywords and Phrases

Biodegradability; Borate Glass/Chitosan Composite; Osteoconductivity; Teicoplanin; antibacterial activity; biodegradation; composite material; drug delivery system; drug release; elution; minimum inhibitory concentration; pH; scanning electron microscopy; surface property; sustained drug release; viscosity; X ray diffraction

International Standard Serial Number (ISSN)

0378-5173

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2010 Elsevier, All rights reserved.

Publication Date

01 Mar 2010

Link to Full Text

Share

 
COinS