"Chiral Molecular Sensing Based on Spatially Selective Coupling Between" by Baojuan Han, Xiaodong Yang et al.
 

Chiral Molecular Sensing Based on Spatially Selective Coupling Between Achiral Metasurface nad Chiral Molecules

Abstract

Detection and identification of chiral molecules are important for pharmaceutical industry, clinical analysis, and food analysis. Here, chiral molecular sensing based on spatially selective coupling between achiral metasurface and chiral molecules is demonstrated. The designed achiral metasurface exhibits strong optical chirality and electric field with dissymmetric distribution, and chiral molecules are selectively placed over the area with large optical chirality to form the coupled metasurface-molecule system with circular dichroism (CD) response for chiral molecular sensing. The CD spectra of the metasurface coupled with pure D-alanine enantiomer, L-alanine enantiomer and their mixtures are examined. The linear relationship between the peak CD value and the enantiomeric excess is demonstrated for the detection and identification of pure enantiomers and their mixtures. Furthermore, the CD response of the coupled system shows potential for the sensing of molar concentration of chiral molecules. Moreover, the effect of spatial location of molecules on the CD response is analyzed to show potential for position sensing of chiral molecules. These results of chiral molecular sensing with achiral metasurface offer new opportunities for advancing biomolecular sensing applications.

Department(s)

Mechanical and Aerospace Engineering

Keywords and Phrases

chiral molecules; metasurface; optical chirality

International Standard Serial Number (ISSN)

2040-8986; 2040-8978

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2025 IOP Publishing, All rights reserved.

Publication Date

01 Mar 2025

Link to Full Text

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